DISCLAIMER: This product is strictly for research use only. It is meant solely for laboratory testing and in vitro studies-not for use in or on humans or animals. All details provided on this site are for educational purposes. It is illegal to introduce this substance into the body. Only licensed professionals should handle it. This item is not intended to be used as a drug, supplement, or cosmetic, and must not be misrepresented as such.
PT-141 (Bremelanotide)
PT-141, also known as Bremelanotide, is a synthetic peptide originally developed from Melanotan II. Unlike traditional treatments, PT-141 works by directly activating receptors in the brain that influence sexual desire. It has been FDA-approved for treating low sexual desire in women and is also studied for its potential benefits in both men and women.
Quantity: 1
All peptides arrive in powdered form for stability
What is PT-141 (Bremelanotide)?
PT-141, also known as Bremelanotide, is a synthetic peptide that activates melanocortin receptors, primarily MC3R and MC4R, in the central nervous system. It is a derivative of Melanotan II, but unlike its parent compound, PT-141 does not significantly affect skin pigmentation. Instead, it is researched and FDA-approved for its role in enhancing sexual desire and arousal, particularly in women.
Potential Benefits Shown in Studies
- Increasing sexual arousal and libido
- Improving erectile function in men
- Enhancing sexual desire in premenopausal women
- Acting on the central nervous system (not hormones)
- Offering benefits without significantly affecting blood pressure or hormones
- Working independently of testosterone or estrogen levels
Mechanisms of Action
PT-141 acts directly on the nervous system, not the vascular system, which differentiates it from drugs like Viagra or Cialis. It works by:
- Stimulating melanocortin receptors in the brain, enhancing libido
- Increasing sexual arousal by acting on MC4R (linked to arousal and motivation)
- Bypassing hormonal pathways, offering effects even in low-testosterone states
- Triggering natural physiological responses associated with sexual readiness
Molecular Structure of PT-141 (Bremelanotide)
Sequence
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular Properties
Note: PT-141 is a cyclized heptapeptide; similar base as Melanotan II with different terminal modification
PT-141 (Bremelanotide) Research Highlights
PT-141 has been shown to increase sexual desire and arousal in premenopausal women with hypoactive sexual desire disorder (HSDD), with results peaking within hours of administration.
In male participants, PT-141 induced strong erectile responses and improved sexual performance—even in men who were unresponsive to PDE5 inhibitors like sildenafil.
PT-141's unique value lies in its brain-based mechanism — acting independently of nitric oxide pathways or testosterone levels.
Injected or intranasally administered PT-141 begins working within 30 to 60 minutes, with effects lasting several hours, making it practical for planned use.
