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Melanotan II
Melanotan II is a synthetic peptide that mimics the action of alpha-melanocyte-stimulating hormone (α-MSH), which plays a key role in skin pigmentation, sexual function, and appetite regulation. It was originally developed as a potential tanning agent and is now researched for its effects on skin tone, libido, and energy balance.
Quantity: 1
All peptides arrive in powdered form for stability
What is Melanotan II?
Melanotan II (MT-II) is a synthetic analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed to stimulate melanin production (pigment in the skin), but has also demonstrated effects on sexual function, appetite regulation, and energy balance. It binds to multiple melanocortin receptors (MC1R–MC5R), particularly MC1R (for tanning) and MC4R (linked to sexual arousal).
Potential Benefits Shown in Studies
- Stimulating natural skin tanning by increasing melanin
- Enhancing libido and improving erectile function
- Reducing appetite and supporting fat loss
- Providing potential UV protection by darkening skin
- Supporting mood and energy levels through CNS effects
- Helping regulate body weight and metabolism
Mechanisms of Action
Melanotan II works by:
- Activating melanocortin receptors in the skin and brain
- Stimulating melanin production in melanocytes (skin cells)
- Enhancing sexual desire and erectile function via MC3R and MC4R activity
- Reducing appetite and affecting metabolic regulation through CNS pathways
Its broad receptor activity explains its diverse physiological effects beyond tanning.
Molecular Structure of Melanotan II
Sequence
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Molecular Properties
Note: "c" denotes a cyclic structure; Nle = norleucine
Melanotan II Research Highlights
MT-II increases melanin levels in the skin, resulting in a deeper tan even with minimal UV exposure. It may offer a protective benefit against UV damage.
In men with erectile dysfunction, Melanotan II demonstrated significant improvements in erection quality and libido, sometimes independent of sexual stimulation.
Melanocortin receptors in the hypothalamus influence hunger signals. MT-II has been shown to reduce food intake and body weight in animal models.
Because of its CNS activity, MT-II may also influence mood, arousal, and energy — though some studies suggest possible nausea or flushing as side effects.
