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AOD-9604

AOD-9604

AOD-9604 (Advanced Obesity Drug) is a modified fragment of human growth hormone (HGH), specifically the lipolytic region (176-191) of the GH molecule. It was originally developed as an anti-obesity treatment and is studied for its ability to promote fat burning without affecting blood sugar or growth hormone levels systemically.

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What is AOD-9604?

AOD-9604 is a modified fragment of human growth hormone (GH), specifically amino acids 176–191. It was developed to isolate the fat-burning effects of GH without its growth-promoting or blood sugar-altering properties. Research has focused on AOD-9604's potential to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat storage), especially in stubborn areas like visceral or abdominal fat.

Potential Benefits Shown in Studies

  • Stimulating fat breakdown (lipolysis)
  • Inhibiting fat formation (lipogenesis)
  • Reducing body fat, especially abdominal fat
  • Supporting metabolism without impacting blood sugar
  • Aiding in weight management and body recomposition
  • Improving cartilage repair and joint health in some studies
  • Acting without significantly influencing IGF-1 or insulin

Mechanisms of Action

Unlike full-length GH, AOD-9604 works independently of the IGF-1 axis. It:

  • Targets beta-adrenergic and GH receptors in adipose tissue
  • Stimulates breakdown of stored fat (lipolysis)
  • Blocks formation of new fat cells (lipogenesis)
  • Does not affect insulin or blood sugar levels, making it metabolically safe
  • Can be administered orally or via injection in research settings

Because it avoids many of the side effects associated with growth hormone, AOD-9604 is considered a safer fat-targeting peptide for study.

Molecular Structure of AOD-9604

AOD-9604 molecular structure

Sequence

Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Molecular Properties

Formula

C₇₈H₁₂₃N₂₃O₂₃S₂

Weight

1815.1 g/mol

Source
PubChem

AOD-9604 Research Highlights

Clinical studies show AOD-9604 reduces abdominal and visceral fat without elevating IGF-1 or causing systemic GH-like effects.

Unlike GH, AOD-9604 has no negative effect on insulin sensitivity or blood glucose, making it suitable for overweight individuals and those with metabolic concerns.

Oral forms of AOD-9604 have shown partial absorption and biological activity, potentially offering a more convenient delivery method.

In vitro research suggests AOD-9604 may also support cartilage regeneration and joint repair, opening the door for orthopedic uses.

Disclaimer: AOD-9604 is not FDA-approved for fat loss or medical use. It is classified as a research compound and is intended for scientific investigation only.

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