DISCLAIMER: This product is strictly for research use only. It is meant solely for laboratory testing and in vitro studies-not for use in or on humans or animals. All details provided on this site are for educational purposes. It is illegal to introduce this substance into the body. Only licensed professionals should handle it. This item is not intended to be used as a drug, supplement, or cosmetic, and must not be misrepresented as such.
MOTS-c
MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c) is a short peptide naturally produced in the mitochondria and involved in regulating metabolism and cellular energy. It plays a key role in how the body handles glucose, fat oxidation, and cellular stress. As a mitochondrial-derived peptide, MOTS-c is being studied for its effects on metabolic health, physical performance, and healthy aging.
Quantity: 1
All peptides arrive in powdered form for stability
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide made up of 16 amino acids. Unlike most peptides, MOTS-c is encoded within mitochondrial DNA and plays a key role in regulating cellular metabolism, insulin sensitivity, fat oxidation, and stress resistance. Its discovery has opened new avenues in metabolic health, anti-aging, and exercise performance research.
Potential Benefits Shown in Studies
- Enhancing energy production and endurance
- Improving insulin sensitivity and glucose regulation
- Supporting fat burning and weight management
- Protecting cells against metabolic and oxidative stress
- Promoting healthy aging and mitochondrial function
- Boosting physical performance in aging individuals
- Activating AMPK (a key energy-sensing pathway)
Mechanisms of Action
MOTS-c works by:
- Activating AMPK, a master regulator of energy homeostasis
- Increasing glucose uptake in muscle and liver cells, improving insulin sensitivity
- Enhancing fat oxidation, promoting the use of fat as fuel
- Improving mitochondrial function and reducing oxidative stress
- Protecting cells under metabolic stress (e.g. high-fat diet, inflammation, aging)
It mimics the benefits of exercise at a cellular level and is often referred to as a "mitochondrial hormone" in longevity research.
Molecular Structure of MOTS-c
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg (13 amino acids)
Molecular Properties
MOTS-c Research Highlights
MOTS-c significantly improves glucose metabolism and reverses insulin resistance, especially in models of obesity or high-fat diets.
Studies show that MOTS-c acts as an exercise mimetic, enhancing endurance and exercise capacity even without physical training.
In animal studies, MOTS-c improved healthspan and lifespan by enhancing mitochondrial stress responses and delaying age-related metabolic decline.
MOTS-c promotes fat breakdown, reduces inflammation, and prevents fat accumulation, even when subjects are exposed to high-calorie diets.
