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MK-677 (Ibutamoren)
MK-677, also known as Ibutamoren, is a long-acting, orally active growth hormone secretagogue that mimics the action of ghrelin. It stimulates the natural release of growth hormone (GH) and IGF-1 without affecting cortisol levels. MK-677 is widely researched for its potential in improving body composition, sleep, recovery, and anti-aging benefits—without the need for injections.
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What is MK-677 (Ibutamoren)?
MK-677, also known as Ibutamoren, is a long-acting growth hormone secretagogue that stimulates the release of GH (growth hormone) and IGF-1 (insulin-like growth factor 1) by mimicking the action of ghrelin. Unlike injectable peptides, MK-677 is taken orally and has become a popular compound in research for its potential to improve body composition, recovery, sleep, and anti-aging outcomes.
Potential Benefits Shown in Studies
- Increasing natural GH and IGF-1 levels
- Promoting lean muscle mass and reducing fat
- Enhancing recovery, strength, and performance
- Improving deep sleep and sleep quality
- Supporting bone density and joint health
- Promoting healthy skin, hair, and tissue repair
- Supporting anti-aging and metabolic wellness
Mechanisms of Action
MK-677 works by:
- Binding to ghrelin receptors (GHSR-1a) in the brain
- Stimulating the natural release of growth hormone and IGF-1
- Extending GH release for over 24 hours with once-daily oral dosing
- Enhancing sleep quality, especially REM sleep
- Supporting tissue repair, fat loss, and lean muscle growth
Its oral bioavailability and long duration make it unique among GH-releasing compounds.
Molecular Structure of MK-677 (Ibutamoren)
Sequence
2-amino-2-methyl-N-[(2R)-1-(1H-indol-3-yl)propan-2-yl]-4-(naphthalen-1-yl)butanamide
Molecular Properties
MK-677 (Ibutamoren) Research Highlights
Studies show that MK-677 increases GH and IGF-1 levels by 60–100%, mimicking the benefits of growth hormone therapy without injections.
In healthy adults and the elderly, MK-677 preserves lean mass, increases muscle strength, and combats age-related sarcopenia.
By improving GH/IGF-1 signaling, MK-677 helps shift body composition toward greater fat oxidation and decreased visceral fat.
MK-677 improves REM and deep sleep quality, which enhances natural GH rhythms, mental clarity, and physical recovery.
