DISCLAIMER: This product is strictly for research use only. It is meant solely for laboratory testing and in vitro studies-not for use in or on humans or animals. All details provided on this site are for educational purposes. It is illegal to introduce this substance into the body. Only licensed professionals should handle it. This item is not intended to be used as a drug, supplement, or cosmetic, and must not be misrepresented as such.
Sermorelin + Ipamorelin (Blend)
Sermorelin and Ipamorelin are studied together for their ability to boost growth hormone through two distinct pathways—GHRH and ghrelin receptor activation—while maintaining a natural pulse and avoiding unwanted hormonal side effects.
Quantity: 1
All peptides arrive in powdered form for stability
Third-Party Verified Purity
Each batch is tested and certified to meet or exceed 99% purity standards.
Made in the USA
Produced in United States WHO/GMP and ISO 9001:2015 certified facilities.
Rigorous Quality Control
Double-tested to ensure the highest quality for the most effective research.
What is Sermorelin + Ipamorelin (Blend)?
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of naturally occurring growth hormone–releasing hormone (GHRH). It stimulates the pituitary gland to release growth hormone (GH) in a natural, pulsatile pattern that closely mimics the body’s own rhythms. Ipamorelin is a selective growth hormone secretagogue (GHS) that activates ghrelin receptors to trigger GH release without significantly affecting cortisol or prolactin levels. In research settings, combining Sermorelin and Ipamorelin is explored for its potential to enhance GH output through dual-pathway stimulation while maintaining a clean hormonal profile.
Mechanisms of Action
Sermorelin + Ipamorelin may work together by:
- Sermorelin: Binding to GHRH receptors to initiate physiologic GH pulses
- Ipamorelin: Activating ghrelin receptors (GHS-R1a) to increase GH pulse amplitude and frequency without large side hormone spikes
- Increasing circulating IGF-1 to support protein synthesis, muscle repair, and tissue regeneration
- Enhancing collagen production, joint health, and recovery capacity in research models
- Supporting fat metabolism and lean muscle preservation through elevated GH and IGF-1
- Providing a balance of frequency (Sermorelin) and amplitude (Ipamorelin) in GH release
Molecular Structure of Blend Components
Sermorelin Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gly
Molecular Properties
Sermorelin + Ipamorelin (Blend) Research Highlights
Sermorelin, a synthetic analog of GHRH (1–29), stimulates the pituitary gland to secrete growth hormone in natural, pulsatile patterns, maintaining feedback control and minimizing desensitization.
Source: pep-pedia
Originally approved in 1997 for treating childhood growth hormone deficiency, Sermorelin showed efficacy in reversing pediatric growth failure without the constant hormonal exposure of direct GH therapy.
Source: Wikipedia
Ipamorelin binds specifically to the ghrelin receptors in the pituitary, inducing growth hormone (GH) release without significantly impacting cortisol, ACTH, or prolactin—offering a cleaner profile compared to other GHRPs.
Source: pep-pedia
Animal studies indicate that Ipamorelin may counteract glucocorticoid-induced muscle catabolism and increase bone mineral content, particularly enhancing tibial growth and bone density in female rats.
Source: sagepub
Ipamorelin closely mimics natural GH secretion patterns by delivering targeted pulses, which helps maintain physiological hormone balance and potentially improves metabolic responses.
Source: propeptidesource
Due to its selectivity and minimal hormonal side effects, Ipamorelin is under investigation as a research tool for muscle recovery, anti-aging protocols, and metabolic studies.
Source: regentherapy