DISCLAIMER: This product is strictly for research use only. It is meant solely for laboratory testing and in vitro studies-not for use in or on humans or animals. All details provided on this site are for educational purposes. It is illegal to introduce this substance into the body. Only licensed professionals should handle it. This item is not intended to be used as a drug, supplement, or cosmetic, and must not be misrepresented as such.

TB-500

TB-500

TB-500 is a synthetic peptide modeled after a naturally occurring protein in the body called Thymosin Beta-4. It is used in research due to its potential to support healing, reduce inflammation, and improve blood flow.

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All peptides arrive in powdered form for stability

What is TB-500?

TB-500 is a synthetic peptide that replicates a portion of Thymosin Beta-4 (Tβ4), a naturally occurring protein found in most human tissues and blood platelets. It is involved in tissue regeneration, cell migration, and immune modulation. Research has focused on TB-500's role in accelerating recovery from muscle, tendon, and ligament injuries, as well as improving cardiovascular and skin repair outcomes.

Potential Benefits Shown in Studies

  • Healing soft tissue like muscles, tendons, and ligaments
  • Promoting blood vessel growth (angiogenesis)
  • Supporting healthy circulation
  • Reducing inflammation and oxidative stress
  • Improving flexibility and recovery in injured tissue
  • Supporting cell migration and tissue repair
  • Enhancing wound healing in skin, eyes, and internal organs

Mechanisms of Action

TB-500's therapeutic potential is largely attributed to:

  • Upregulating actin-binding proteins to support cell structure and migration
  • Promoting angiogenesis (the growth of new blood vessels)
  • Reducing inflammation and oxidative stress at injury sites
  • Stimulating satellite cell differentiation to repair muscle tissue
  • Improving circulation and oxygen delivery to damaged tissues

Molecular Structure of TB-500

TB-500 molecular structure

Sequence

Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

Molecular Properties

Formula

C₂₁₂H₃₅₀N₅₆O₇₈S

Weight

4963.49 g/mol

Source
PubChem

TB-500 Research Highlights

Studies show TB-500 enhances recovery in ligaments, tendons, and muscles. It promotes regeneration by supporting cellular migration, boosting collagen production, and reducing fibrosis after injury.

Research in animal models suggests that Thymosin Beta-4 and TB-500 may improve cardiac function after injury by promoting new blood vessel formation and reducing scar tissue (fibrosis).

TB-500 has been studied for its role in accelerating skin wound closure by enhancing keratinocyte migration, collagen remodeling, and local angiogenesis.

TB-500 has demonstrated the ability to modulate inflammatory responses and may play a role in balancing immune activity during healing.

Disclaimer: TB-500 is classified as a research compound and is not approved for human consumption. This content is intended for educational purposes only.

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