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Thymosin Alpha-1

Thymosin Alpha-1

Thymosin Alpha-1 is a naturally occurring peptide originally isolated from the thymus gland. It plays a central role in regulating and boosting the immune system. Tα1 has been studied extensively for its potential to enhance immune defense, fight infections, and support the body's ability to respond to stress, illness, and cancer. It is also FDA-approved in some countries for use in immune-related conditions.

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All peptides arrive in powdered form for stability

What is Thymosin Alpha-1?

Thymosin Alpha-1 (Tα1) is a synthetic version of a naturally occurring peptide fragment derived from prothymosin alpha, a protein involved in regulating the immune system. Tα1 has been extensively studied for its role in immune modulation, infection resistance, and anti-tumor activity. It has been used internationally as an immunotherapeutic agent, especially in cases of viral infections and immune suppression.

Potential Benefits Shown in Studies

  • Strengthening the immune system
  • Supporting the body in fighting viral and bacterial infections
  • Enhancing vaccine response and immune regulation
  • Promoting T-cell activity and natural killer (NK) cell function
  • Reducing inflammation and oxidative stress
  • Supporting recovery during illness or immune suppression
  • Helping regulate abnormal immune activity (autoimmunity, cancer research)

Mechanisms of Action

Thymosin Alpha-1 enhances immunity by:

  • Stimulating T-cell production and activation
  • Increasing natural killer (NK) cell activity
  • Promoting dendritic cell maturation, improving antigen presentation
  • Enhancing cytokine regulation, especially interferons and interleukins
  • Balancing immune response, avoiding excessive inflammation or suppression

It is known for strengthening host defense mechanisms without overstimulating the immune system.

Molecular Structure of Thymosin Alpha-1

Thymosin Alpha-1 molecular structure

Sequence

Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asp-Glu-Asn (28 amino acids)

Molecular Properties

Formula

C₁₂₉H₂₁₄N₅₆O₅₅

Weight

~3108.33 g/mol

Source
PubChem

Thymosin Alpha-1 Research Highlights

Tα1 has been shown to improve immune response in patients with chronic infections like hepatitis B, hepatitis C, and HIV by boosting T-cell activity.

Thymosin Alpha-1 is used in combination with chemotherapy or interferon in cancer patients, helping enhance immune surveillance and reduce tumor progression.

Recent studies have explored Tα1 as a supportive therapy in COVID-19, noting reductions in inflammatory markers and better immune regulation in severe cases.

Tα1 has also been studied for rebalancing dysregulated immune responses in autoimmune diseases and countering age-related immune decline.

Disclaimer: Thymosin Alpha-1 is not FDA-approved for general use in the United States and is classified as a research peptide. This content is for educational purposes only.

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