DISCLAIMER: This product is strictly for research use only. It is meant solely for laboratory testing and in vitro studies-not for use in or on humans or animals. All details provided on this site are for educational purposes. It is illegal to introduce this substance into the body. Only licensed professionals should handle it. This item is not intended to be used as a drug, supplement, or cosmetic, and must not be misrepresented as such.
Tesamorelin + Ipamorelin (Blend)
Tesamorelin and Ipamorelin are two peptides that stimulate growth hormone release through separate pathways—Tesamorelin via the GHRH receptor and Ipamorelin via the ghrelin receptor—with research exploring their complementary effects on GH output.
Quantity: 1
All peptides arrive in powdered form for stability
Third-Party Verified Purity
Each batch is tested and certified to meet or exceed 99% purity standards.
Made in the USA
Produced in United States WHO/GMP and ISO 9001:2015 certified facilities.
Rigorous Quality Control
Double-tested to ensure the highest quality for the most effective research.
What is Tesamorelin + Ipamorelin (Blend)?
Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) that stimulates the pituitary gland to release growth hormone (GH) through the natural GHRH pathway. It has a 44–amino acid structure with modifications that increase its stability and half-life compared to natural GHRH. Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist that triggers GH release via a separate pathway from GHRH. When used together in research settings, Tesamorelin and Ipamorelin may have complementary effects on GH release by acting on two different hormonal signaling mechanisms.
Mechanisms of Action
Tesamorelin + Ipamorelin may work together by:
- Tesamorelin: Binding to GHRH receptors in the pituitary to increase GH pulse amplitude and frequency
- Ipamorelin: Activating ghrelin receptors (GHS-R1a) to enhance GH secretion without significantly affecting cortisol or prolactin levels
- Potentially increasing circulating insulin-like growth factor-1 (IGF-1) to support tissue growth and repair
- Acting synergistically to promote a greater and more sustained GH release than either peptide alone
- Supporting protein synthesis, tissue recovery, and metabolic regulation in research models
Molecular Structure of Blend Components
Tesamorelin Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-NH₂
Molecular Properties
Tesamorelin + Ipamorelin (Blend) Research Highlights
Tesamorelin (Egrifta®) is FDA-approved for reducing visceral adipose tissue (VAT) in patients with HIV-associated lipodystrophy, with clinical trials demonstrating significant VAT loss and improvements in body composition, lipid profile, and insulin sensitivity.
Source: Metical Anti-Aging Evidence
Emerging research is exploring Tesamorelin’s effects beyond HIV lipodystrophy, including reducing hepatic steatosis and liver fibrosis in NAFLD, improving cognitive function, insulin resistance, and other aging-related metabolic markers.
Current Phase II trials are evaluating Tesamorelin’s potential in improving cognitive function in aging HIV populations, and in enhancing motor and sensory recovery after peripheral nerve injuries.
Tesamorelin has been shown to improve lipid metabolism—lowering triglycerides by ~15% and increasing HDL—while maintaining or even enhancing insulin sensitivity, and improving glucose homeostasis.
Ipamorelin binds specifically to the ghrelin receptors in the pituitary, inducing growth hormone (GH) release without significantly impacting cortisol, ACTH, or prolactin—offering a cleaner profile compared to other GHRPs.
Source: pep-pedia
Animal studies indicate that Ipamorelin may counteract glucocorticoid-induced muscle catabolism and increase bone mineral content, particularly enhancing tibial growth and bone density in female rats.
Source: sagepub
Ipamorelin closely mimics natural GH secretion patterns by delivering targeted pulses, which helps maintain physiological hormone balance and potentially improves metabolic responses.
Source: propeptidesource
Due to its selectivity and minimal hormonal side effects, Ipamorelin is under investigation as a research tool for muscle recovery, anti-aging protocols, and metabolic studies.
Source: regentherapy