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Tesamorelin
Tesamorelin is a synthetic peptide that stimulates the release of growth hormone by mimicking the body's natural Growth Hormone-Releasing Hormone (GHRH). It is FDA-approved for reducing excess abdominal fat in HIV-positive patients with lipodystrophy and is also being studied for its potential effects on body composition, metabolism, and healthy aging.
Variant: 5 mg
Quantity: 1
All peptides arrive in powdered form for stability
What is Tesamorelin?
Tesamorelin is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH 1-44) developed to stimulate the pituitary gland's natural production of growth hormone (GH). It is FDA-approved for reducing visceral adipose tissue (VAT) in HIV-positive adults with lipodystrophy and is also being researched for broader applications in fat loss, metabolism, cognitive function, and liver health.
Potential Benefits Shown in Studies
- Increasing natural growth hormone production
- Reducing deep belly fat (visceral adipose tissue)
- Supporting lean muscle growth and recovery
- Improving lipid (cholesterol) profiles
- Enhancing metabolic health and insulin sensitivity
- Supporting cognitive function and memory
- Promoting healthy aging and body composition
Mechanisms of Action
Tesamorelin works by:
- Binding to GHRH receptors in the pituitary gland
- Stimulating pulsatile release of GH, mimicking natural secretion
- Raising circulating IGF-1 levels, supporting tissue growth and metabolism
- Promoting lipolysis (fat breakdown), especially in visceral fat deposits
Unlike exogenous GH, Tesamorelin preserves the body's feedback loops and reduces the risk of GH oversaturation.
Molecular Structure of Tesamorelin
Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-NH₂
Molecular Properties
Tesamorelin Research Highlights
Tesamorelin was shown to reduce VAT by 15–20% in patients with HIV-associated lipodystrophy without significantly affecting subcutaneous fat.
Clinical studies show Tesamorelin reduces liver fat content and slows the progression of nonalcoholic steatohepatitis (NASH) by reducing inflammatory markers and fibrosis progression.
In a randomized controlled trial, Tesamorelin improved cognitive performance and working memory in older adults with HIV, suggesting a role in brain health and possibly age-related neuroprotection.
Tesamorelin increases IGF-1 levels in a safe, controlled manner and improves lipid profiles — including reductions in triglycerides and improvements in insulin sensitivity.
